Yes, it does.
RFC does not require receiving servers to respect any Reply-To, and they can choose to reply to any of these: From, Reply-To, Return-Path, or even the List-Unsubscribe-Email or Postmaster or Abuse, the latter three especially if any of the standard header email addresses is spoofed/wrong. This also why PhpMailer is actually compliant, while SwiftMailer (much slower by 2.6x) only looks compliant.
Ideally you have From, Reply-To, Return-Path one and the same, so the receiving server "has no doubt" (spam probability) and your chance of inboxing is higher.
Ideally you have From, Reply-To, Return-Path one and the same, so the receiving server "has no doubt" (spam probability) and your chance of inboxing is higher.